The role of inflammation in the development of epilepsy

A Rana, AE Musto - Journal of neuroinflammation, 2018 - Springer
Epilepsy, a neurological disease characterized by recurrent seizures, is often associated
with a history of previous lesions in the nervous system. Impaired regulation of the activation …

GAD antibodies in neurological disorders—insights and challenges

F Graus, A Saiz, J Dalmau - Nature Reviews Neurology, 2020 - nature.com
Antibodies to glutamic acid decarboxylase (GAD) have been associated with several
neurological syndromes, including stiff-person syndrome, cerebellar ataxia and epilepsy …

Cerebrospinal fluid findings in patients with autoimmune encephalitis—a systematic analysis

T Blinder, J Lewerenz - Frontiers in neurology, 2019 - frontiersin.org
Autoimmune encephalitides (AIE) comprise a group of inflammatory diseases of the central
nervous system (CNS), which can be further characterized by the presence of different …

[HTML][HTML] Stiff-person syndrome and GAD antibody-spectrum disorders: GABAergic neuronal excitability, immunopathogenesis and update on antibody therapies

MC Dalakas - Neurotherapeutics, 2022 - Elsevier
Abstract Although antibodies against Glutamic Acid Decarboxylase (GAD) were originally
associated with Stiff Person Syndrome (SPS), they now denote the “GAD antibody-spectrum …

GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions

P Tsiortou, H Alexopoulos… - Therapeutic advances in …, 2021 - journals.sagepub.com
Antibodies against glutamic acid decarboxylase (GAD), originally linked to stiff person
syndrome (SPS), now denote the “GAD antibody-spectrum disorders”(GAD-SD) that also …

GAD65 neurological autoimmunity

A McKeon, JA Tracy - Muscle & Nerve, 2017 - Wiley Online Library
The glutamic acid decarboxylase 65‐kilodalton isoform (GAD65) antibody is a biomarker of
autoimmune central nervous system (CNS) disorders and, more commonly, nonneurological …

Seizures and risk of epilepsy in anti‐NMDAR, anti‐LGI1, and anti‐GABABR encephalitis

CH Shen, GL Fang, F Yang, MT Cai… - Annals of Clinical …, 2020 - Wiley Online Library
Background Accumulating data have suggested seizures occur frequently in patients with
neuronal surface antibody‐mediated autoimmune encephalitis. We aimed to evaluate …

Antiglutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy

A Daif, RV Lukas, NP Issa, A Javed, S VanHaerents… - Epilepsy & Behavior, 2018 - Elsevier
Glutamic acid decarboxylase (GAD) antibody-associated encephalitis causes both acute
seizures and chronic epilepsy with predominantly temporal lobe onset. This condition is …

Seizure specificities in patients with antibody‐mediated autoimmune encephalitis

A Vogrig, B Joubert, N André‐Obadia, GL Gigli… - …, 2019 - Wiley Online Library
Accumulating data on patients with autoimmune encephalitis have shed light on specificities
concerning clinical presentation and outcomes, which are dependent on the antigen …

Stiff person syndrome and GAD antibody–spectrum disorders

MC Dalakas - CONTINUUM: Lifelong Learning in Neurology, 2024 - journals.lww.com
OBJECTIVE Antibodies against glutamic acid decarboxylase (GAD), originally associated
with stiff person syndrome (SPS), define the GAD antibody–spectrum disorders that also …