Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …

Although increasing evidence confirms neuropsychiatric manifestations associated mainly
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …

One increasingly documented tendency of COVID-19 patients is to exhibit neuropsychiatric
and neurological symptoms. Here we found that anxiety and cognitive impairment are …

Huntington disease (HD) is a monogenic disease that results in a combination of motor,
psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion …

Intracellular vesicular transport along cytoskeletal filaments ensures targeted cargo delivery.
Such transport is rarely unidirectional but rather bidirectional, with frequent directional …

The endolysosomal system is present in all cell types. Within these cells, it performs a series
of essential roles, such as trafficking and sorting of membrane cargo, intracellular signaling …

Patients with Huntington's disease (HD) have an increased incidence of diabetes. However,
the molecular mechanisms of pancreatic β-cell dysfunction have not been entirely clarified …

Rab GTPases (Rabs) are small proteins that play crucial roles in vesicle transport and
membrane trafficking. Owing to their widespread functions in several steps of vesicle …

Mitochondria are highly dynamic organelles with strict quality control processes that
maintain cellular homeostasis. Within axons, coordinated cycles of fission-fusion mediated …