The essential role of tick salivary glands and saliva in tick feeding and pathogen transmission

L Šimo, M Kazimirova, J Richardson… - Frontiers in cellular and …, 2017 - frontiersin.org
As long-term pool feeders, ticks have developed myriad strategies to remain discreetly but
solidly attached to their hosts for the duration of their blood meal. The critical biological …

Serpins in arthropod biology

DA Meekins, MR Kanost, K Michel - Seminars in cell & developmental …, 2017 - Elsevier
Serpins are the largest known family of serine proteinase inhibitors and perform a variety of
physiological functions in arthropods. Herein, we review the field of serpins in arthropod …

Host immune responses to salivary components-a critical facet of tick-host interactions

A Ali, I Zeb, A Alouffi, H Zahid, MM Almutairi… - Frontiers in Cellular …, 2022 - frontiersin.org
Tick sialome is comprised of a rich cocktail of bioactive molecules that function as a tool to
disarm host immunity, assist blood-feeding, and play a vibrant role in pathogen …

Proteomic Analysis of Cattle Tick Rhipicephalus (Boophilus) microplus Saliva: A Comparison between Partially and Fully Engorged Females

L Tirloni, J Reck, RMS Terra, JR Martins, A Mulenga… - PloS one, 2014 - journals.plos.org
The cattle tick Rhipicephalus (Boophilus) microplus is one of the most harmful parasites
affecting bovines. Similarly to other hematophagous ectoparasites, R. microplus saliva …

Protease inhibitors in tick saliva: the role of serpins and cystatins in tick-host-pathogen interaction

J Chmelař, J Kotál, H Langhansová… - Frontiers in cellular and …, 2017 - frontiersin.org
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of
research of tick protease inhibitors, which represent important constituents of the proteins …

A comprehensive phylogenetic analysis of the serpin superfamily

MA Spence, MD Mortimer, AM Buckle… - Molecular Biology …, 2021 - academic.oup.com
Serine protease inhibitors (serpins) are found in all kingdoms of life and play essential roles
in multiple physiological processes. Owing to the diversity of the superfamily, phylogenetic …

Serpins in tick physiology and tick-host interaction

MN Abbas, A Chlastáková, MA Jmel… - Frontiers in Cellular …, 2022 - frontiersin.org
Tick saliva has been extensively studied in the context of tick-host interactions because it is
involved in host homeostasis modulation and microbial pathogen transmission to the host …

Potential mechanisms of transmission of tick-borne viruses at the virus-tick interface

M Maqbool, MS Sajid, M Saqib, FR Anjum… - Frontiers in …, 2022 - frontiersin.org
Ticks (Acari; Ixodidae) are the second most important vector for transmission of pathogens to
humans, livestock, and wildlife. Ticks as vectors for viruses have been reported many times …

Serine protease inhibitors in ticks: an overview of their role in tick biology and tick-borne pathogen transmission

AA Blisnick, T Foulon, SI Bonnet - Frontiers in Cellular and Infection …, 2017 - frontiersin.org
New tick and tick-borne pathogen control approaches that are both environmentally
sustainable and which provide broad protection are urgently needed. Their development …

Ixodes scapularis nymph saliva protein blocks host inflammation and complement-mediated killing of Lyme disease agent, Borrelia burgdorferi

E Bencosme-Cuevas, TK Kim, TT Nguyen… - Frontiers in Cellular …, 2023 - frontiersin.org
Tick serine protease inhibitors (serpins) play crucial roles in tick feeding and pathogen
transmission. We demonstrate that Ixodes scapularis (Ixs) nymph tick saliva serpin (S) 41 …