Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Obesity predisposes individuals to the development of insulin resistance in skeletal muscle
and the liver, and researchers have recently proposed two mechanisms by which excess …

Summary Insulin resistance occurs in 20%–25% of the human population, and the condition
is a chief component of type 2 diabetes mellitus and a risk factor for cardiovascular disease …

OBJECTIVE Chronic exercise and obesity both increase intramyocellular triglycerides
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …

Obesity and dyslipidemia are risk factors for metabolic disorders including diabetes and
cardiovascular disease. Sphingolipids such as ceramide and glucosylceramides, while …

Lipids as fuel for energy provision originate from different sources: albumin-bound long-
chain fatty acids (LCFA) in the blood plasma, circulating very-low-density lipoproteins …

Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable
proportion of the human population and severely compromise quality of life. Therefore …

BACKGROUND. Accumulation of diacylglycerol (DAG) and sphingolipids is thought to
promote skeletal muscle insulin resistance by altering cellular signaling specific to their …

OBJECTIVE Age-associated insulin resistance may underlie the higher prevalence of type 2
diabetes in older adults. We examined a corollary hypothesis that obesity and level of …

An epidemic surge in the incidence of obesity has occurred worldwide over the past two
decades. This alarming trend has been triggered by lifestyle habits that encourage …