Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

Synchronizing circadian (24 h) rhythms in physiology and behavior with the environmental
light-dark cycle is critical for maintaining optimal health. Dysregulation of the circadian …

Evidence for the importance of sleep in the mood disorders has mushroomed over the past
decade. Among adolescents and adults with a mood disorder, sleep disturbance is a risk …

An association with circadian clock function and pathophysiology of aging, major depressive
disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed …

This paper reviews recent work on the biological underpinnings of clinical depression
emphasizing the crucial role of immunoinflammatory and oxidative and nitrosative stress …

Most organisms (including humans) developed daily rhythms in almost every aspect of their
body. It is not surprising that rhythms are also related to affect in health and disease. In the …

The circadian clock machinery is responsible for biological timekeeping on a systemic level.
The central clock system controls peripheral clocks through a number of output cues that …

Abstract Circadian (~ 24 h) rhythms in physiology and behavior are evolutionarily conserved
and found in almost all living organisms. The rhythms are endogenously driven by daily …

Objectives Bipolar disorder is a common psychiatric disease characterized by mood
disturbances with alternating episodes of mania and depression. Moreover, disturbances in …

It has been suggested for some time that circadian rhythm abnormalities underlie the
development of multiple psychiatric disorders. However, it is unclear how disruptions in …