Biomolecular condensates are membraneless organelle-like structures that can concentrate
molecules and often form through liquid-liquid phase separation. Biomolecular condensate …

Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid that has
been used for centuries in Chinese medicine. Chemically, TUDCA is a taurine conjugate of …

Abstract Stress Granules (SGs) and Processing-bodies (P-bodies) are biomolecular
condensates formed in the cell with the highly conserved purpose of maintaining balance …

Folding and unfolding are essential ways for a protein to regulate its biological activity. The
misfolding of proteins usually reduces or completely compromises their biological functions …

Maintaining protein homeostasis (proteostasis) is essential for cellular health and is
governed by a network of quality control machinery comprising over 800 genes. When …

G protein-coupled receptors (GPCRs) are plasma membrane proteins associated with an
array of functions. Mutations in these receptors lead to a number of genetic diseases …

Highlights•A cyclized xylanase was constructed using the SpyTag/SpyCatcher
system.•SpyTag/SpyCatcher cyclization enhanced thermostability and ion-stability of …

Osmolytes are small organic biomolecules utilized by cells and organisms to counter
unfavorable physiological conditions that challenge protein stability and function. Among …

The endoplasmic reticulum (ER) is responsible for folding secretory and membrane proteins,
but disturbed ER proteostasis may lead to protein aggregation and subsequent cellular and …

Trimethylamine-N-oxide (TMAO) is a low molecular weight metabolite whose production is
dependent on metabolism of its precursors choline, carnitine, creatinine, betaine or lecithin …