The loss of control over drug intake that occurs in addiction was initially believed to result
from disruption of subcortical reward circuits. However, imaging studies in addictive …

Rationale and objective Empirical studies indicate that nicotine enhances some aspects of
attention and cognition, suggesting a role in the maintenance of tobacco dependence. The …

The last 15 years have witnessed a steady increase in the number of resting-state functional
neuroimaging studies. The connectivity patterns of multiple functional, distributed, large …

Despite intensive scientific investigation and public health imperatives, drug addiction
treatment outcomes have not significantly improved in more than 50years. Non-invasive …

The anterior cingulate cortex (ACC) is part of a network implicated in the development of self-
regulation and whose connectivity changes dramatically in development. In previous studies …

Foraging theory prescribes when optimal foragers should leave the current option for more
rewarding alternatives. Actual foragers often exploit options longer than prescribed by the …

We discuss the idea that addictions can be treated by changing the mechanisms involved in
self-control with or without regard to intention. The core clinical symptoms of addiction …

More than 5 million deaths a year are attributable to tobacco smoking, but attempts to help
people either quit or reduce their smoking often fail, perhaps in part because the intention to …

A better understanding of carbon dioxide (CO2) effect on brain activity may have a profound
impact on clinical studies using CO2 manipulation to assess cerebrovascular reserve and …

It is widely accepted that addictive drug use is related to abnormal functional organization in
the user's brain. The present study aimed to identify this type of abnormality within the brain …