Plant molecular farming: A viable platform for recombinant biopharmaceutical production

B Shanmugaraj, CJ I. Bulaon, W Phoolcharoen - Plants, 2020 - mdpi.com
The demand for recombinant proteins in terms of quality, quantity, and diversity is increasing
steadily, which is attracting global attention for the development of new recombinant protein …

Plant-made vaccine antigens and biopharmaceuticals

H Daniell, ND Singh, H Mason, SJ Streatfield - Trends in plant science, 2009 - cell.com
Plant cells are ideal bioreactors for the production and oral delivery of vaccines and
biopharmaceuticals, eliminating the need for expensive fermentation, purification, cold …

The gut is the epicentre of antibiotic resistance

J Carlet - Antimicrobial resistance and infection control, 2012 - Springer
The gut contains very large numbers of bacteria. Changes in the composition of the gut flora,
due in particular to antibiotics, can happen silently, leading to the selection of highly …

The mucosal immune system for vaccine development

A Lamichhane, T Azegami, H Kiyono - Vaccine, 2014 - Elsevier
Mucosal surfaces are continuously exposed to the external environment and therefore
represent the largest lymphoid organ of the body. In the mucosal immune system, gut …

Plants as bioreactors for the production of vaccine antigens

S Tiwari, PC Verma, PK Singh, R Tuli - Biotechnology advances, 2009 - Elsevier
Plants have been identified as promising expression systems for commercial production of
vaccine antigens. In phase I clinical trials several plant-derived vaccine antigens have been …

Chloroplast‐derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery

A Davoodi‐Semiromi, M Schreiber… - Plant biotechnology …, 2010 - Wiley Online Library
Cholera and malaria are major diseases causing high mortality. The only licensed cholera
vaccine is expensive; immunity is lost in children within 3 years and adults are not fully …

AB toxins: a paradigm switch from deadly to desirable

O Odumosu, D Nicholas, H Yano, W Langridge - Toxins, 2010 - mdpi.com
To ensure their survival, a number of bacterial and plant species have evolved a common
strategy to capture energy from other biological systems. Being imperfect pathogens …

Progress and hurdles in the development of vaccines against enterotoxigenic Escherichia coli in humans

W Zhang, DA Sack - Expert review of vaccines, 2012 - Taylor & Francis
Diarrhea is the second leading cause of death in children younger than 5 years.
Enterotoxigenic Escherichia coli (ETEC) strains are the most common bacterial cause of …

Recent progress in the development of plant derived vaccines

V Yusibov, S Rabindran - Expert review of vaccines, 2008 - Taylor & Francis
Recombinant subunit vaccines have been with us for the last 30 years and they provide us
with the unique opportunity to choose from the many available production systems that can …

Plant platforms for efficient heterologous protein production

SB Ghag, VS Adki, TR Ganapathi, VA Bapat - … and Bioprocess Engineering, 2021 - Springer
Production of recombinant proteins is primarily established in cultures of mammalian, insect
and bacterial cells. Concurrently, concept of using plants to produce high-value …