Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …

Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical
cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes …

In contrast to mammals, zebrafish regenerate heart injuries via proliferation of
cardiomyocytes located near the wound border. To identify regulators of cardiomyocyte …

Abstract Electrophilic aldehyde (4-hydroxynonenal; 4-HNE), formed after lipid peroxidation,
is a mediator of mitochondrial dysfunction and implicated in both the pathogenesis and the …

The efficiency of the repair process following ischemic cardiac injury is a crucial determinant
for the progression into heart failure and is controlled by both intra-and intercellular …

Background: Surviving cells in the postinfarction border zone are subjected to intense
fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been …

Background: Cardiac ischemic injury induces a pathological remodeling response, which
can ultimately lead to heart failure. Detailed mechanistic insights into molecular signaling …

The rate of contraction of the heart relies on proper development and function of the
sinoatrial node, which consists of a small heterogeneous cell population, including Tbx3+ …

Transcriptional regulation of thousands of genes instructs complex morphogenetic and
molecular events for heart development. Cardiac transcription factors choreograph gene …

The embryonic vertebrate heart tube develops an atrioventricular canal that divides the atrial
and ventricular chambers, forms atrioventricular conduction tissue and organizes valve …