Chemical synapses provide a vital foundation for neuron-neuron communication and overall
brain function. By tethering closely apposed molecular machinery for presynaptic …

The genetics underlying autism spectrum disorder (ASD) is complex and heterogeneous,
and de novo variants are found in genes converging in functional biological processes …

Background Endocannabinoid dysfunction in animal models of autism spectrum disorder
(ASD) and accumulating, albeit anecdotal, evidence for efficacy in humans motivated this …

Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …

The endocannabinoid (eCB) system encompasses the eCBs anandamide and 2-
arachidonoylglycerol, their anabolic/catabolic enzymes, and the cannabinoid CB1 and CB2 …

Neuroligins are postsynaptic cell adhesion molecules that are relevant to many
neurodevelopmental disorders. They are differentially enriched at the postsynapse and …

Cannabis is well established to impact affective states, emotion and perceptual processing,
primarily through its interactions with the endocannabinoid system. While cannabis use is …

Gastrointestinal (GI) problems constitute an important comorbidity in many patients with
autism. Multiple mutations in the neuroligin family of synaptic adhesion molecules are …

The therapeutic benefits of the current medications for patients with psychiatric disorders
contrast with a great variety of adverse effects. The endocannabinoid system (ECS) …

Abstract Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-
motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of …