Astrocytes: a central element in neurological diseases
The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …
primary component in the pathogenesis of neurological diseases. As this concept is …
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Astrocytes are the most abundant cells in the central nervous system (CNS) that provide
nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis …
nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis …
The dual role of astrocyte activation and reactive gliosis
Astrocyte activation and reactive gliosis accompany most of the pathologies in the brain,
spinal cord, and retina. Reactive gliosis has been described as constitutive, graded, multi …
spinal cord, and retina. Reactive gliosis has been described as constitutive, graded, multi …
Mitochondrial dysfunction in depression
Y Bansal, A Kuhad - Current neuropharmacology, 2016 - ingentaconnect.com
Background: Depression is the most debilitating neuropsychiatric disorder with significant
impact on socio-occupational and well being of individual. The exact pathophysiology of …
impact on socio-occupational and well being of individual. The exact pathophysiology of …
[HTML][HTML] Reactive gliosis in the pathogenesis of CNS diseases
Astrocytes maintain the homeostasis of the central nervous system (CNS) by eg recycling of
neurotransmitters and providing nutrients to neurons. Astrocytes function also as key …
neurotransmitters and providing nutrients to neurons. Astrocytes function also as key …
Neural tissue engineering: strategies for repair and regeneration
CE Schmidt, JB Leach - Annual review of biomedical …, 2003 - annualreviews.org
▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …
KLF family members regulate intrinsic axon regeneration ability
Neurons in the central nervous system (CNS) lose their ability to regenerate early in
development, but the underlying mechanisms are unknown. By screening genes …
development, but the underlying mechanisms are unknown. By screening genes …
The cellular neurobiology of depression
Major depressive disorders, long considered to be of neurochemical origin, have recently
been associated with impairments in signaling pathways that regulate neuroplasticity and …
been associated with impairments in signaling pathways that regulate neuroplasticity and …
[HTML][HTML] Mitochondrial control of apoptosis: the role of cytochrome c
Mitochondrial cytochrome c (cyt c) has been found to have dual functions in controlling both
cellular energetic metabolism and apoptosis. Through interaction with apoptotic protease …
cellular energetic metabolism and apoptosis. Through interaction with apoptotic protease …
In animal models, psychosocial stress-induced (neuro) inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression
M Kubera, E Obuchowicz, L Goehler, J Brzeszcz… - Progress in Neuro …, 2011 - Elsevier
Recently, the inflammatory and neurodegenerative (I&ND) hypothesis of depression was
formulated (Maes et al., 2009), ie the neurodegeneration and reduced neurogenesis that …
formulated (Maes et al., 2009), ie the neurodegeneration and reduced neurogenesis that …