Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

When viruses infect cells, they almost invariably cause metabolic changes in the infected
cell as well as in several host cell types that react to the infection. Such metabolic changes …

Viral replication is a process that involves an extremely high turnover of cellular molecules.
Since viruses depend on the host cell to obtain the macromolecules needed for their proper …

HIV persists in long-lived infected cells that are not affected by antiretroviral treatment. These
HIV reservoirs are mainly located in CD4+ T cells, but their distribution is variable in the …

The primary interactions between incoming viral RNA genomes and host proteins are crucial
to infection and immunity. Until now, the ability to study these events was lacking. We …

Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral
infections. Metabolic reprogramming provides the cell with energy and biomass for large …

Lipid metabolites are emerging as pivotal regulators of protein function and cell signaling.
The availability of intracellular fatty acid is tightly regulated by glycolipid metabolism and …

The circadian clock regulates immune responses to microbes and affects pathogen
replication, but the underlying molecular mechanisms are not well understood. Here we …

Chikungunya virus (CHIKV) is transmitted to people by mosquitoes, and CHIKV infection
causes fever and joint pain. Fatty acid synthase (FASN) has been identified as a proviral …

The emergence and re-emergence of viral diseases, which cause significant global mortality
and morbidity, are the major concerns of this decade. Of these, current research is focused …