Microtubule-severing enzymes generate internal breaks in microtubules. They are
conserved in eukaryotes from ciliates to mammals, and their function is important in diverse …

Nanoparticle size plays a central role in determining material properties and performance in
biomedical applications. A wide variety of functional nanomaterials and nano-bioconjugates …

Microtubule organization has a crucial role in regulating cell architecture. The geometry of
microtubule arrays strongly depends on the distribution of sites responsible for microtubule …

CRISPR defence systems such as the well-known DNA-targeting Cas9 and the RNA-
targeting type III systems are widespread in prokaryotes,. The latter orchestrates a complex …

Microtubules are dynamic polymers consisting of αβ-tubulin heterodimers. The initial
polymerization process, called microtubule nucleation, occurs spontaneously via αβ-tubulin …

Non-centrosomal microtubule-organizing centres (ncMTOCs) have a variety of roles that are
presumed to serve the diverse functions of the range of cell types in which they are found …

Axons are the slender, cable-like, up to meter-long projections of neurons that electrically
wire our brains and bodies. In spite of their challenging morphology, they usually need to be …

The 12 related human ESCRT-III proteins form filaments that constrict membranes and
mediate fission, including during cytokinetic abscission. The C-terminal tails of polymerized …

Microtubules are cytoskeletal polymers that separate chromosomes during mitosis and
serve as rails for intracellular transport and organelle positioning. Manipulation of …

Microtubules are dynamic cytoskeletal filaments that undergo stochastic switching between
phases of polymerization and depolymerization—a behavior known as dynamic instability …