Enzyme-responsive microneedle patch for bacterial infection and accelerated healing of diabetic wounds

S Wu, B Qin, X Tang, T Cui, S Yin, H Dong, Y Liu… - Chemical Engineering …, 2023 - Elsevier
Chronic diabetic wounds are caused by an array of pathologies. Pathogenic bacteria such
as S. aureus can easily invade hosts with deficient immunity. In this study, we developed a …

Tissue engineering of the retina: from organoids to microfluidic chips

LF Marcos, SL Wilson, P Roach - Journal of tissue …, 2021 - journals.sagepub.com
Despite advancements in tissue engineering, challenges remain for fabricating functional
tissues that incorporate essential features including vasculature and complex cellular …

Eye-on-a-chip (EOC) models and their role in the future of ophthalmic drug discovery

Z Peng, L Zhou, JKW Wong… - Expert Review of …, 2020 - Taylor & Francis
With the increasing prevalence of debilitating eye diseases such as age-related macular
degeneration, glaucoma, and dryeye syndromes, there is a pressing need for the …

[HTML][HTML] Harnessing the neuroprotective behaviors of Müller glia for retinal repair

JS Peña, M Vazquez - Frontiers in bioscience (Landmark edition), 2022 - ncbi.nlm.nih.gov
Progressive and irreversible vision loss in mature and aging adults creates a health and
economic burden, worldwide. Despite the advancements of many contemporary therapies to …

Müller glia in retinal development: from specification to circuit integration

JM Tworig, MB Feller - Frontiers in Neural Circuits, 2022 - frontiersin.org
Müller glia of the retina share many features with astroglia located throughout the brain
including maintenance of homeostasis, modulation of neurotransmitter spillover, and robust …

Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility

JM Tworig, CJ Coate, MB Feller - Elife, 2021 - elifesciences.org
Neural activity has been implicated in the motility and outgrowth of glial cell processes
throughout the central nervous system. Here, we explore this phenomenon in Müller glia …

Antioxidants derived from natural products reduce radiative damage in cultured retinal glia to prevent oxidative stress

RN Cliver, N Castro, T Russomano, G Lardieri… - Neuroglia, 2022 - mdpi.com
Retinal pathologies have been heavily studied in response to radiation and microgravity,
including spaceflight-associated neuro-ocular syndrome (SANS), which is commonly …

A milled microdevice to advance glia-mediated therapies in the adult nervous system

JS Peña, D Robles, S Zhang, M Vazquez - Micromachines, 2019 - mdpi.com
Neurodegenerative disorders affect millions of adults worldwide. Neuroglia have become
recent therapeutic targets due to their reparative abilities in the recycling of exogenous …

Müller Glia to Müller Glia Extracellular Vesicle-Dependent Signaling Induces Multipotency Genes Nestin and lin28 Expression in Response to N-methyl-D-aspartate …

AK Carapia, EJ Martinez-Colin… - ASN …, 2023 - journals.sagepub.com
A strict localization into the neural retina and the capacity to survive many pathogenic
conditions are unique characteristics of Müller glia. Retinal damage induces cellular and …

Microfluidic and microscale assays to examine regenerative strategies in the neuro retina

M Vazquez - Micromachines, 2020 - mdpi.com
Bioengineering systems have transformed scientific knowledge of cellular behaviors in the
nervous system (NS) and pioneered innovative, regenerative therapies to treat adult neural …