Quantifying the benefit of early antibiotic treatment is crucial for decision making and can be
assessed only in observational studies. We performed a systematic review of prospective …

Polymyxins have re-emerged in clinical practice owing to the dry antibiotic development
pipeline and worldwide increasing prevalence of nosocomial infections caused by multidrug …

Background Data on the use of ceftolozane-tazobactam and emergence of ceftolozane-
tazobactam resistance during multidrug resistant (MDR)-Pseudomonas aeruginosa …

Bloodstream infections (BSIs) caused by Klebsiella pneumoniae carbapenemases (KPC)-
producing K. pneumoniae (KPC-KP) are associated with high mortality rates. We …

International and local surveillance networks as well as numerous reports in the biomedical
literature provide evidence that the prevalence of antibiotic resistant Gram-negative bacteria …

Pseudomonas aeruginosa is an uncommon cause of community-acquired pneumonia
(CAP), but a common cause of hospital-acquired pneumonia. Controversies exist for …

Background: The most common hospital-acquired pathogen is Pseudomonas aeruginosa. It
is a multidrug resistant bacterium causing systemic infections. Objectives: The present study …

Pseudomonas aeruginosa is an important cause of nosocomial pneumonia associated with
a high morbidity and mortality rate. This bacterium expresses a variety of factors that confer …

Scandinavia is considered a region with a low prevalence of antimicrobial resistance.
However, the number of multidrug-resistant (MDR) Gram-negative bacteria is increasing …

Purpose Carbapenem-resistant Enterobacterales bloodstream infections (CRE BSIs) have a
high mortality. However, an optimal antimicrobial treatment has not been determined. This …