The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Reactive oxygen species and cancer paradox: to promote or to suppress?

S Galadari, A Rahman, S Pallichankandy… - Free Radical Biology …, 2017 - Elsevier
Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Reactive oxygen species: a volatile driver of field cancerization and metastasis

Z Liao, D Chua, NS Tan - Molecular cancer, 2019 - Springer
Field cancerization and metastasis are the leading causes for cancer recurrence and
mortality in cancer patients. The formation of primary, secondary tumors or metastasis is …

The interplay of reactive oxygen species, hypoxia, inflammation, and sirtuins in cancer initiation and progression

M Tafani, L Sansone, F Limana… - Oxidative medicine …, 2016 - Wiley Online Library
The presence of ROS is a constant feature in living cells metabolizing O2. ROS
concentration and compartmentation determine their physiological or pathological effects …

Redox signaling at the crossroads of human health and disease

J Zuo, Z Zhang, M Luo, L Zhou, EC Nice, W Zhang… - MedComm, 2022 - Wiley Online Library
Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …

Targeting the NFκB signaling pathways for breast cancer prevention and therapy

W Wang, SA Nag, R Zhang - Current medicinal chemistry, 2015 - ingentaconnect.com
The activation of nuclear factor-kappaB (NFΚB), a proinflammatory transcription factor, is a
commonly observed phenomenon in breast cancer. It facilitates the development of a …

Reactive oxygen species (ROS) are a key determinant of cancer's metabolic phenotype

S Rodic, MD Vincent - International journal of cancer, 2018 - Wiley Online Library
Cancer cells exhibit a wide range of metabolic phenotypes, ranging from strict aerobic
glycolysis to increased mitochondrial respiration. The cause and utility of this metabolic …

Transforming growth factor‐beta and oxidative stress interplay: implications in tumorigenesis and cancer progression

J Krstić, D Trivanović, S Mojsilović… - … medicine and cellular …, 2015 - Wiley Online Library
Transforming growth factor‐beta (TGF‐β) and oxidative stress/Reactive Oxygen Species
(ROS) both have pivotal roles in health and disease. In this review we are analyzing the …

[HTML][HTML] Neuroimmune function and the consequences of alcohol exposure

FT Crews, DK Sarkar, L Qin, J Zou… - Alcohol research …, 2015 - ncbi.nlm.nih.gov
Induction of neuroimmune genes by binge drinking increases neuronal excitability and
oxidative stress, contributing to the neurobiology of alcohol dependence and causing …

Inflammasome-independent NLRP3 augments TGF-β signaling in kidney epithelium

W Wang, X Wang, J Chun, A Vilaysane… - The Journal of …, 2013 - journals.aai.org
Tubulointerstitial inflammation and fibrosis are strongly associated with the outcome of
chronic kidney disease. We recently demonstrated that the NOD-like receptor, pyrin domain …