The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial
roles in vasculogenesis and angiogenesis. Angiogenesis is an important mechanism in …

Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

Recruitment of tumor-associated macrophages (TAMs) into avascular areas sustains tumor
progression; however, the underlying guidance mechanisms are unknown. Here, we report …

Sprouting angiogenesis is a dynamic process in which endothelial cells collectively migrate,
shape new lumenized tubes, make new connections, and remodel the nascent network into …

An adult animal consists of cells of vastly different size and activity, but the regulation of cell
size remains poorly understood. Recent studies uncovering some of the signaling pathways …

Vascular and nervous systems, two major networks in mammalian bodies, show a high
degree of anatomical parallelism and functional crosstalk. During development, neurons …

Vascular endothelial growth factor A (VEGF-A) is best known for its essential roles in blood
vessel growth. However, evidence has emerged that VEGF-A also promotes a wide range of …

Semaphorins are key players in the control of neural circuit development. Recent studies
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …

Vascular endothelial growth factor-A (VEGF-A) has long been recognized as the key
regulator of vascular development and function in health and disease. VEGF is a secreted …

Semaphorins are secreted and membrane-associated proteins that regulate many different
developmental processes, including neural circuit assembly, bone formation and …