Biological sex differences refer to differences between males and females caused by the sex
chromosome complement (that is, XY or XX), reproductive tissues (that is, the presence of …

Hypertension is an increasingly pressing public health concern across the globe. It can be
triggered by a variety of factors such as age and diet, as well as the stress of modern life …

Recently, we have reported that the early progression of proteinuria in the obese Dahl salt-
sensitive (SS) leptin receptor mutant (SSLepRmutant) strain was associated with increased …

TNF-α (tumor necrosis factor-alpha) is the best known as a proinflammatory cytokine; yet,
this cytokine also has important immunomodulatory and regulatory functions. As the effects …

Preeclampsia (PE), a leading cause of maternal/fetal morbidity and mortality, is a
hypertensive pregnancy disorder with end-organ damage that manifests after 20 wk of …

With the incidence of hypertension increasing worldwide, more and more the mechanisms of
hypertension from the perspective of immunity have found. Intestinal microbiota as well as its …

To explore the mechanism of Lingguizhugan Decoction in treating hypertension based on
network pharmacology and molecular simulation. The active ingredients and potential …

The traditional Chinese medicinal herb Salvia miltiorrhiza Bunge (SM) is widely used for
hypertension complications, yet its mechanism remains undefined. This study assessed SM …

Abstract Type 17 T helper (Th17) cells, which are a subtype of CD4+ T helper cells, secrete
pro-inflammatory cytokines such as IL-17A, IL-17F, IL-21, IL-22, and GM-CSF, which play …

Sex is an important biological variable that impacts several organism functions at the
genetic, molecular, and cellular levels. Sex differences are observed in all components of …