Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for
fine-tuning the spatial and temporal expression of a broad range of genes both during …

The unfolded protein response (UPR) is activated upon the accumulation of misfolded
proteins in the endoplasmic reticulum (ER) that are sensed by the binding immunoglobulin …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

Bile acids are synthesized in the liver and are the major component in bile. Impaired bile
flow leads to cholestasis that is characterized by elevated levels of bile acid in the liver and …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

In liver and intestine, transporters play a critical role in maintaining the enterohepatic
circulation and bile acid homeostasis. Over the past two decades, there has been significant …

The forkhead box (Fox) family of transcription factors, which originated in unicellular
eukaryotes, has expanded over time through multiple duplication events, and sometimes …

The hepatocyte is especially vulnerable to injury due to its central role in xenobiotic
metabolism including drugs and alcohol, participation in lipid and fatty acid metabolism, its …

Hepatocellular carcinoma (HCC) is sexually dimorphic in both rodents and humans, with
significantly higher incidence in males, an effect that is dependent on sex hormones. The …