[HTML][HTML] Structural basis for the functional diversity of centrins: A focus on calcium sensing properties and target recognition

M Pedretti, L Bombardi, C Conter, F Favretto… - International Journal of …, 2021 - mdpi.com
Centrins are a family of small, EF hand-containing proteins that are found in all eukaryotes
and are often complexed with centrosome-related structures. Since their discovery, centrins …

Calcium decoders and their targets: The holy alliance that regulate cellular responses in stress signaling.

B Ravi, SK Sanyal, GK Pandey - Advances in Protein Chemistry …, 2023 - europepmc.org
Calcium (Ca2+) signaling is versatile communication network in the cell. Stimuli perceived
by cells are transposed through Ca2+-signature, and are decoded by plethora of Ca2+ …

[HTML][HTML] Genome-wide analysis of the apple CBL family reveals that Mdcbl10. 1 functions positively in modulating apple salt tolerance

P Chen, J Yang, Q Mei, H Liu, Y Cheng, F Ma… - International Journal of …, 2021 - mdpi.com
Abiotic stresses are increasingly harmful to crop yield and quality. Calcium and its signaling
pathway play an important role in modulating plant stress tolerance. As specific Ca2+ …

[HTML][HTML] Catalytic specificity and crystal structure of cystathionine γ-lyase from Pseudomonas aeruginosa

M Pedretti, C Fernández-Rodríguez, C Conter… - Scientific Reports, 2024 - nature.com
The escalating drug resistance among microorganisms underscores the urgent need for
innovative therapeutic strategies and a comprehensive understanding of bacteria's defense …

[HTML][HTML] Role of myristoylation in modulating PCaP1 interaction with calmodulin

M Pedretti, F Favretto, F Troilo, M Giovannoni… - Plant Physiology and …, 2023 - Elsevier
Plasma membrane-associated Cation-binding Protein 1 (PCaP1) belongs to the plant-
unique DREPP protein family with largely unknown biological functions but ascertained …

The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii

C Conter, L Bombardi, M Pedretti, F Favretto… - Biochemical …, 2021 - portlandpress.com
Centrins are conserved calcium (Ca2+)-binding proteins typically associated with
centrosomes that have been implicated in several biological processes. In Toxoplasma …

Rapid sequence and functional diversification of a miRNA superfamily targeting calcium signaling components in seed plants

K Attri, Z Zhang, A Singh, RA Sharrock, Z Xie - New Phytologist, 2022 - Wiley Online Library
MicroRNA (miRNA)‐directed posttranscriptional gene silencing (miR‐PTGS) is an integral
component of gene regulatory networks governing plant development and responses to the …

[HTML][HTML] Distinct Calcium Binding and Structural Properties of Two Centrin Isoforms from Toxoplasma gondii

L Bombardi, M Pedretti, C Conter, P Dominici… - Biomolecules, 2020 - mdpi.com
Centrins are calcium (Ca2+)-binding proteins that have been implicated in several
regulatory functions. In the protozoan parasite Toxoplasma gondii, the causative agent of …

Rapid kinetics of calcium dissociation from plant calmodulin and calmodulin-like proteins and effect of target peptides

F Troilo, M Pedretti, C Travaglini-Allocatelli… - Biochemical and …, 2022 - Elsevier
Abstract Calcium (Ca 2+) signaling represents a universal information code in plants,
playing crucial roles spanning developmental processes to stress responses. Ca 2+ signals …

Evaluating the potential of non‐immunosuppressive cyclosporin analogs for targeting Toxoplasma gondii cyclophilin: Insights from structural studies

F Favretto, E Jiménez‐Faraco, G Catucci… - Protein …, 2024 - Wiley Online Library
Toxoplasmosis persists as a prevalent disease, facing challenges from parasite resistance
and treatment side effects. Consequently, identifying new drugs by exploring novel protein …