Epigenetic mechanisms—including DNA methylation, histone post-translational
modifications and changes in nucleosome positioning—regulate gene expression, cellular …

The essential amino acid tryptophan is not only a precursor of serotonin but is also
degraded to several other neuroactive compounds, including kynurenic acid, 3 …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease. HD
patients present with movement disorders, behavioral and psychiatric symptoms and …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

The kynurenine (Kyn) pathway is the major route for tryptophan (Trp) metabolism, and it
contributes to several fundamental biological processes. Trp is constitutively oxidized by …

Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have
been closely linked to the pathogenesis of several neurodegenerative diseases. Tryptophan …

Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …

Currently, the concept of 'neuroinflammation'includes inflammation associated with
neurodegenerative diseases, in which there is little or no infiltration of blood-derived …

Microglia are the main immune cells in the brain, playing a role in both physiological and
pathological conditions. Microglial involvement in neurodegenerative diseases is well …

Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have
been implicated in the pathophysiology of neurodegenerative disorders, including …