A review on biological and medicinal significance of thiazoles
PM Jadhav, S Kantevari, AB Tekale… - … , Sulfur, and Silicon …, 2021 - Taylor & Francis
Thiazole, a five-membered heterocyclic compound constitutes the skeleton of various
commercially marketed drug candidates and the heart-core in a diverse range of entities of …
commercially marketed drug candidates and the heart-core in a diverse range of entities of …
Chalcone scaffolds as anticancer drugs: a review on molecular insight in action of mechanisms and anticancer properties
Cancer is the deadliest disease worldwide and the development of safer chemical entities to
treat cancer is one of the major challenges of medicinal chemistry. The emergence of new …
treat cancer is one of the major challenges of medicinal chemistry. The emergence of new …
Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm …
AY Alzahrani, YA Ammar, M Abu-Elghait, MA Salem… - Bioorganic …, 2022 - Elsevier
Nowadays, it's imperative to develop novel antimicrobial agents active against both drug-
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …
New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity
New series of thiazole and imidazo [2, 1-b] thiazole derivatives were synthesized and tested
for their in vitro anticancer activity. Compounds 27, 34, 39 and 42–44 showed the best …
for their in vitro anticancer activity. Compounds 27, 34, 39 and 42–44 showed the best …
[HTML][HTML] Discovery of new Schiff bases tethered pyrazole moiety: Design, synthesis, biological evaluation, and molecular docking study as dual targeting DHFR/DNA …
A series of Bis-pyrazole Schiff bases (6a–d and 7a–d) and mono-pyrazole Schiff bases (8a–
d and 9a–d) were designed and synthesized through the reaction of 5-aminopyrazoles 1a–d …
d and 9a–d) were designed and synthesized through the reaction of 5-aminopyrazoles 1a–d …
One-pot strategy for thiazole tethered 7-ethoxy quinoline hybrids: Synthesis and potential antimicrobial agents as dihydrofolate reductase (DHFR) inhibitors with …
YA Ammar, SMA Abd El-Hafez, SA Hessein… - Journal of Molecular …, 2021 - Elsevier
Over the world and especially the developing countries, one of the major threats to human
health is antibiotic resistance due to antibiotics abuse. This challenge can be solved by …
health is antibiotic resistance due to antibiotics abuse. This challenge can be solved by …
A novel of azo-thiazole moiety alternative for benzidine-based pigments: design, synthesis, characterization, biological evaluation, and molecular docking study
A new series of coloring compounds (pigments) based on 5-(2-aminothiazol-5-yl) thiazol-2-
amine and 5-(4-aminophenyl) thiazol-2-amine as heterocyclic alternatives for benzidine …
amine and 5-(4-aminophenyl) thiazol-2-amine as heterocyclic alternatives for benzidine …
Nb/starch-doped ZnO nanostructures for polluted water treatment and antimicrobial applications: molecular docking analysis
Nb/starch-doped ZnO quantum dots (QDs) were prepared by a coprecipitation route. A fixed
quantity of starch (st) and different concentrations (2 and 4%) of niobium (Nb) were doped in …
quantity of starch (st) and different concentrations (2 and 4%) of niobium (Nb) were doped in …
Biological role of chalcones in medicinal chemistry
Chalcones are promising synthons and bioactive scaffolds of great medicinal interest due to
their numerous pharmacological and biological activities. They are well recognized to …
their numerous pharmacological and biological activities. They are well recognized to …
Potential bacterial biofilm, MRSA, and DHFR inhibitors based on new morpholine-linked chromene-thiazole hybrids: One-pot synthesis and in silico study
We report herein the utility of the morpholine-linked benzaldehyde as a key building block in
the preparation of two series of new chromene-thiazoles with potential bioactivities. In this …
the preparation of two series of new chromene-thiazoles with potential bioactivities. In this …