Impact of endemic infections on HIV susceptibility in sub-Saharan Africa
Human immunodeficiency virus (HIV) remains a leading cause of global morbidity with the
highest burden in Sub-Saharan Africa (SSA). For reasons that are incompletely understood …
highest burden in Sub-Saharan Africa (SSA). For reasons that are incompletely understood …
Antihelminthics in helminth‐endemic areas: effects on HIV disease progression
Background Helminth infections, such as soil‐transmitted helminths, schistosomiasis,
onchocerciasis, and lymphatic filariasis, are prevalent in many countries where human …
onchocerciasis, and lymphatic filariasis, are prevalent in many countries where human …
Wuchereria bancrofti infection is linked to systemic activation of CD4 and CD8 T cells
I Kroidl, M Chachage, J Mnkai, A Nsojo… - PLoS neglected …, 2019 - journals.plos.org
Background Susceptibility to HIV has been linked to systemic CD4+ T cell activation in
cohorts of seronegative individuals with high HIV-exposure risk. We recently described an …
cohorts of seronegative individuals with high HIV-exposure risk. We recently described an …
High frequency of HIV precursor-target-specific B cells in sub-Saharan populations
F Matassoli, A Cagigi, CH Shen, AR Henry… - Cell reports, 2023 - cell.com
HIV gp120 engineered outer domain germline-targeting version 8 (eOD-GT8) was designed
specifically to engage naive B cell precursors of VRC01-class antibodies. However, the …
specifically to engage naive B cell precursors of VRC01-class antibodies. However, the …
Changes in genital tract immune cell populations after initiation of intrauterine contraception
Objective The primary target cells for the human immunodeficiency virus (HIV) infection in
the genital tract are CD4 T cells that express CCR5 on the surface. Alterations in genital tract …
the genital tract are CD4 T cells that express CCR5 on the surface. Alterations in genital tract …
Chronic Immune Activation and CD4+ T Cell Lymphopenia in Healthy African Individuals: Perspectives for SARS-CoV-2 Vaccine Efficacy
D Wolday, FM Ndungu, GP Gómez-Pérez… - Frontiers in …, 2021 - frontiersin.org
Chronic immune activation has been considered as the driving force for CD4+ T cell
depletion in people infected with HIV-1. Interestingly, the normal immune profile of adult HIV …
depletion in people infected with HIV-1. Interestingly, the normal immune profile of adult HIV …
Nitric Oxide from IFNγ-Primed Macrophages Modulates the Antimicrobial Activity of β-Lactams against the Intracellular Pathogens Burkholderia pseudomallei and Nontyphoidal …
J Jones-Carson, AE Zweifel, T Tapscott… - PLoS Neglected …, 2014 - journals.plos.org
Our investigations show that nonlethal concentrations of nitric oxide (NO) abrogate the
antibiotic activity of β-lactam antibiotics against Burkholderia pseudomallei, Escherichia coli …
antibiotic activity of β-lactam antibiotics against Burkholderia pseudomallei, Escherichia coli …
Anti-HIV Activity and Immunomodulatory Properties of Fractionated Crude Extracts of Alternaria alternata
MX Kubheka, SI Ndlovu, NP Mkhwanazi - Microorganisms, 2024 - mdpi.com
Developing new anti-human immunodeficiency virus (HIV) drug candidates that target
different sites in HIV-1 replication, with better resistance profiles and lower drug toxicity, is …
different sites in HIV-1 replication, with better resistance profiles and lower drug toxicity, is …
Interleukin-10 and soil-transmitted helminth infections in Honduran children
AL Sanchez, DL Mahoney, JA Gabrie - BMC research notes, 2015 - Springer
Background Soil-transmitted helminths (STH) establish chronic infections in the human
intestine. The host reacts to these infections with a dominant T-helper type 2 cell (Th2) …
intestine. The host reacts to these infections with a dominant T-helper type 2 cell (Th2) …
Association between different anti-Tat antibody isotypes and HIV disease progression: data from an African cohort
F Nicoli, M Chachage, P Clowes, A Bauer… - BMC Infectious …, 2016 - Springer
Abstract Background The presence of IgG and IgM against Tat, an HIV protein important for
viral replication and immune dysfunction, is associated with slow disease progression in …
viral replication and immune dysfunction, is associated with slow disease progression in …