The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Organisms from all domains of life depend on filaments of the protein actin to provide
structure and to support internal movements. Many eukaryotic cells use forces produced by …

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …

Many fundamental cellular processes such as division, polarization, endocytosis, and
motility require the assembly, maintenance, and disassembly of filamentous actin (F-actin) …

Adhesion and morphogenesis of many non-muscle cells are guided by contractile
actomyosin bundles called ventral stress fibers. While it is well established that stress fibers …

Force transmission through the actin cytoskeleton plays a central role in cell movements,
shape change, and internal organization. Dynamic reorganization of actin filaments by an …

Neurons begin their life as simple spheres, but can ultimately assume an elaborate
morphology with numerous, highly arborized dendrites, and long axons. This is achieved via …

ABSTRACT Globular (G)-actin, the actin monomer, assembles into polarized filaments that
form networks that can provide structural support, generate force and organize the cell …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are the central regulators of
actin filament disassembly. A key function of ADF/cofilin is to sever actin filaments. However …