The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Fibrotic scars deposited during skin wound healing can cause disfiguration and loss of
dermal function. Scar differentiation involves inputs from multiple cell types in a predictable …

Skin fibrosis is a physiopathological process featuring the excessive deposition of
extracellular matrix (ECM), which is the main architecture that provides structural support …

Gap junctions are specialized cell-to-cell contacts that allow the direct transfer of small
molecules between cells. A single gap junction channel consists of two hemichannels, or …

Recent studies showed that mesenchymal stem cell (MSC) transplantation significantly
alleviated tissue fibrosis; however, little is known about the efficacy on attenuating …

The gap junction protein, connexin43 (Cx43), has critical roles in the inflammatory,
edematous, and fibrotic processes following dermal injury and during wound healing, and is …

The most ubiquitous gap junction protein within the body, connexin 43 (Cx43), is a target of
interest for modulating the dermal wound healing response. Observational studies found …

Nonhealing neuropathic foot ulcers remain a significant problem in individuals with
diabetes. The gap‐junctional protein connexin43 (Cx43) has roles in dermal wound healing …

Aim: Gap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing–
including scarring. The aim here was to study the effects of a cell-permeant peptide from the …