Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging
supplements, and even pet food. It is well-defined as a therapy for preventing diabetic …

Diabetes is a chronic metabolic disease with a high prevalence worldwide. Diabetes and
insulin resistance are associated with the development of cardiovascular and nervous …

Insulin resistance is a cardinal feature of type 2 diabetes and is characteristic of a wide
range of other clinical and experimental settings. Little is known about why insulin resistance …

High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a
major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction …

Background The molecular nature of lipoic acid (LA) clarifies its capability of taking part to a
variety of biochemical reactions where redox state is meaningful. The pivotal action of LA is …

Alpha-lipoic acid is a naturally occurring substance, essential for the function of different
enzymes that take part in mitochondria's oxidative metabolism. It is believed that alpha-lipoic …

Diabetes has emerged as a major threat to worldwide health. The exact mechanisms
underlying the disease are unknown; however, there is growing evidence that the excess …

Reactive oxygen (ROS) and nitrogen oxide (RNOS) species are produced as by-products of
oxidative metabolism. A major function for ROS and RNOS is immunological host defense …

Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties
which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely …

α-Lipoic acid (ALA) has been identified as a powerful antioxidant found naturally in our diets,
but appears to have increased functional capacity when given as a supplement in the form …