Gene body methylation in cancer: molecular mechanisms and clinical applications

Q Wang, F Xiong, G Wu, W Liu, J Chen, B Wang… - Clinical …, 2022 - Springer
DNA methylation is an important epigenetic mechanism that regulates gene expression. To
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …

DNA methylation pathways and their crosstalk with histone methylation

J Du, LM Johnson, SE Jacobsen… - Nature reviews Molecular …, 2015 - nature.com
Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

RNA-directed DNA methylation: an epigenetic pathway of increasing complexity

MA Matzke, RA Mosher - Nature Reviews Genetics, 2014 - nature.com
RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic
pathway in plants. RdDM requires a specialized transcriptional machinery that comprises …

Epigenetic mechanisms of plant adaptation to biotic and abiotic stresses

VV Ashapkin, LI Kutueva, NI Aleksandrushkina… - International journal of …, 2020 - mdpi.com
Unlike animals, plants are immobile and could not actively escape the effects of aggressive
environmental factors, such as pathogenic microorganisms, insect pests, parasitic plants …

[HTML][HTML] The Arabidopsis nucleosome remodeler DDM1 allows DNA methyltransferases to access H1-containing heterochromatin

A Zemach, MY Kim, PH Hsieh, D Coleman-Derr… - Cell, 2013 - cell.com
Nucleosome remodelers of the DDM1/Lsh family are required for DNA methylation of
transposable elements, but the reason for this is unknown. How DDM1 interacts with other …

Widespread dynamic DNA methylation in response to biotic stress

RH Dowen, M Pelizzola, RJ Schmitz… - Proceedings of the …, 2012 - National Acad Sciences
Regulation of gene expression by DNA methylation is crucial for defining cellular identities
and coordinating organism-wide developmental programs in many organisms. In plants …

[HTML][HTML] Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome

H Stroud, MVC Greenberg, S Feng, YV Bernatavichute… - Cell, 2013 - cell.com
Cytosine methylation is involved in various biological processes such as silencing of
transposable elements (TEs) and imprinting. Multiple pathways regulate DNA methylation in …

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

JA Law, SE Jacobsen - Nature Reviews Genetics, 2010 - nature.com
Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological
processes, including gene and transposon silencing, imprinting and X chromosome …

Somaclonal variation—Advantage or disadvantage in micropropagation of the medicinal plants

G Duta-Cornescu, N Constantin, DM Pojoga… - International journal of …, 2023 - mdpi.com
Cell and tissue plant cultures are used either to save vulnerable species from extinction or to
multiply valuable genotypes, or both, and are widely applied for economically important …

Plant DNA methylation: an epigenetic mark in development, environmental interactions, and evolution

F Lucibelli, MC Valoroso, S Aceto - International Journal of Molecular …, 2022 - mdpi.com
DNA methylation is an epigenetic modification of the genome involved in the regulation of
gene expression and modulation of chromatin structure. Plant genomes are widely …