[HTML][HTML] Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

Sepsis-induced immunosuppression

LK Torres, P Pickkers… - Annual review of …, 2022 - annualreviews.org
Sepsis is expected to have a substantial impact on public health and cost as its prevalence
increases. Factors contributing to increased prevalence include a progressively aging …

[HTML][HTML] A pairwise cytokine code explains the organism-wide response to sepsis

M Takahama, A Patil, G Richey, D Cipurko… - Nature …, 2024 - nature.com
Sepsis is a systemic response to infection with life-threatening consequences. Our
understanding of the molecular and cellular impact of sepsis across organs remains …

Natural products and their derivatives as immune check point inhibitors: Targeting cytokine/chemokine signalling in cancer

M Gupta, K Chandan, M Sarwat - Seminars in cancer biology, 2022 - Elsevier
Cancer immunotherapy is the new generation and widely accepted form of tumour
treatment. It is, however, associated with exclusive challenges which include organ-specific …

[HTML][HTML] Treatment advances in sepsis and septic shock: modulating pro-and anti-inflammatory mechanisms

A Marques, C Torre, R Pinto, B Sepodes… - Journal of Clinical …, 2023 - mdpi.com
Sepsis is currently defined as a life-threatening organ dysfunction caused by a dysregulated
host response to infection, and it affects over 25 million people every year. Even more …

Lymphopenia in sepsis—an acquired immunodeficiency?

S Finfer, B Venkatesh, RS Hotchkiss… - Immunology and Cell …, 2023 - Wiley Online Library
Sepsis is a global health priority, yet effective host‐directed targeted therapies have not
been identified outside of the setting of coronavirus disease 2019 (COVID‐19) …

Broad-Spectrum Clearance of Lipopolysaccharides from Blood Based on a Hemocompatible Dihistidine Polymer

J Chen, Z Shi, X Yang, X Zhang, D Wang… - … Applied Materials & …, 2023 - ACS Publications
Blood infection can release toxic bacterial lipopolysaccharides (LPSs) into bloodstream,
trigger a series of inflammatory reactions, and eventually lead to multiple organ dysfunction …

[HTML][HTML] Targeting the host response in sepsis: current approaches and future evidence

C Bode, S Weis, A Sauer, P Wendel-Garcia, S David - Critical Care, 2023 - Springer
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of
the leading causes of death worldwide. Disbalances of the immune response play an …

[HTML][HTML] Evaluation of the molecular mechanisms of sepsis using proteomics

H Miao, S Chen, R Ding - Frontiers in Immunology, 2021 - frontiersin.org
Sepsis is a complex syndrome promoted by pathogenic and host factors; it is characterized
by dysregulated host responses and multiple organ dysfunction, which can lead to death …

The pathogenesis and potential therapeutic targets in sepsis

W Zhang, H Jiang, G Wu, P Huang, H Wang, H An… - MedComm, 2023 - Wiley Online Library
Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection.” At present, sepsis continues to …