Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Simple Summary Alzheimer's disease (AD) is the most common neurodegenerative disease,
intensifying impairments in cognition, behavior, and memory. Histopathological AD …

Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

One of the hallmarks of Alzheimer's disease (AD) pathogenesis is the production,
aggregation, and deposition of amyloid-β (Aβ) peptide. Surface-enhanced Raman …

According to the amyloid cascade hypothesis, metal ions, mainly Cu and Zn ions, bound to
the amyloid-β (Aβ) peptides are implicated in Alzheimer's disease (AD), a widespread …

Heavy metals, including lead (Pb), cadmium (Cd), arsenic (As), cobalt (Co), copper (Cu),
manganese (Mn), zinc (Zn), and others, have a significant impact on the development and …

Among inorganic materials, divalent cations modulate thousands of physiological processes
that support life. Their roles in protein assembly and aggregation are less known, although …

Metal ions play a key role in aggregation of amyloid β protein by interfering with their proper
folding, altering protein homeostasis and cell viability, and ultimately leading to …

Aging is associated with an increasing dysfunction of key brain homeostasis mechanisms
and represents the main risk factor across most neurodegenerative disorders. However, the …

Abstract Zn2+‐induced β‐amyloid protein (Aβ) aggregation and microglia activation are the
predominant contributors in Alzheimer's disease (AD). Regulating intracephalic excessive …