The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Conduct disorder (CD) is a common and highly impairing psychiatric disorder that usually
emerges in childhood or adolescence and is characterized by severe antisocial and …

Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Even though the importance of epigenetics was first recognized in light of its role in tissue
development, an increasing amount of evidence has shown that it also plays an important …

Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …

Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a
complex risk structure thought to be influenced by interactions between genetic variants and …

Differential DNA methylation in the brain is associated with many psychiatric diseases, but
access to brain tissues is essentially limited to postmortem samples. The use of surrogate …

Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …

Background Exposure to early-life adversity is known to predict DNA methylation (DNAm)
patterns that may be related to psychiatric risk. However, few studies have investigated …

Biological embedding occurs when life experience alters biological processes to affect later
life health and well-being. Although extensive correlative data exist supporting the notion …