Carboranes in drug discovery, chemical biology and molecular imaging

A Marfavi, P Kavianpour, LM Rendina - Nature Reviews Chemistry, 2022 - nature.com
There exists a paucity of structural innovation and limited molecular diversity associated with
molecular frameworks in drug discovery and biomolecular imaging/chemical probe design …

The boron advantage: the evolution and diversification of boron's applications in medicinal chemistry

K Messner, B Vuong, GK Tranmer - Pharmaceuticals, 2022 - mdpi.com
In this review, the history of boron's early use in drugs, and the history of the use of boron
functional groups in medicinal chemistry applications are discussed. This includes …

Boron cluster compounds as new chemical leads for antimicrobial therapy

K Fink, M Uchman - Coordination Chemistry Reviews, 2021 - Elsevier
Boron cluster compounds are inorganic compounds with chemical compositions and
structures vastly different from those of organic compounds, albeit with the ability to form a …

New keys for old locks: Carborane-containing drugs as platforms for mechanism-based therapies

P Stockmann, M Gozzi, R Kuhnert, MB Sárosi… - Chemical Society …, 2019 - pubs.rsc.org
Icosahedral carboranes in medicine are still an emerging class of compounds with potential
beneficial applications in drug design. These highly hydrophobic clusters are potential “new …

Challenges and opportunities for the application of boron clusters in drug design

ZJ Lesnikowski - Journal of medicinal chemistry, 2016 - ACS Publications
There are two branches in boron medicinal chemistry: the first focuses on single boron atom
compounds, and the second utilizes boron clusters. Boron clusters and their heteroatom …

[HTML][HTML] Retroviral proteases and their roles in virion maturation

J Konvalinka, HG Kräusslich, B Müller - Virology, 2015 - Elsevier
Proteolytic processing of viral polyproteins is essential for retrovirus infectivity. Retroviral
proteases (PR) become activated during or after assembly of the immature, non-infectious …

Boron‐based drug design

HS Ban, H Nakamura - The Chemical Record, 2015 - Wiley Online Library
The use of the element boron, which is not generally observed in a living body, possesses a
high potential for the discovery of new biological activity in pharmaceutical drug design. In …

Carborane-or metallacarborane-linked nucleotides for redox labeling. Orthogonal multipotential coding of all four DNA bases for electrochemical analysis and …

D Kodr, CP Yenice, A Simonova, DP Saftić… - Journal of the …, 2021 - ACS Publications
We report a series of 2′-deoxyribonucleoside triphosphates bearing dicarba-nido-
undecaborate ([C2B9H11] 1–),[3, 3′-iron-bis (1, 2-dicarbollide)]−(FESAN,[Fe (C2B9H11) 2] …

The dominant role of chalcogen bonding in the crystal packing of 2D/3D aromatics

J Fanfrlík, A Přáda, Z Padělková, A Pecina… - Angewandte …, 2014 - Wiley Online Library
The chalcogen bond is a nonclassical σ‐hole‐based noncovalent interaction with emerging
applications in medicinal chemistry and material science. It is found in organic compounds …

Recent developments with boron as a platform for novel drug design

ZJ Leśnikowski - Expert opinion on drug discovery, 2016 - Taylor & Francis
Introduction: After decades of development, the medicinal chemistry of compounds that
contain a single boron atom has matured to the present status of having equal rights with …