Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …

Despite substantial progress in the development of antiretroviral regimens that durably
suppress Human Immunodeficiency Virus (HIV) infection, new agents that maintain high …

Background Tenofovir alafenamide shows high antiviral efficacy and improved renal and
bone safety compared with tenofovir disoproxil fumarate when used for HIV treatment. Here …

Hepatitis B virus (HBV) infection remains a global public health problem with changing
epidemiology due to several factors including vaccination policies and migration. This …

Importance New data and therapeutic options warrant updated recommendations for the use
of antiretroviral drugs (ARVs) to treat or to prevent HIV infection in adults. Objective To …

Background The novel prodrug tenofovir alafenamide delivers the nucleotide reverse
transcriptase inhibitor tenofovir to target cells more efficiently at a lower dose than tenofovir …

Background: Tenofovir-based antiretroviral therapy (ART) has become first-line in all major
HIV treatment guidelines. Compared with tenofovir disoproxil fumarate (TDF), tenofovir …

The newest class of antiretrovirals for all persons living with HIV are the integrase strand
transfer inhibitors (INSTIs). Since 2007, five INSTIs have been introduced: raltegravir …

Introduction: Although weight gain has been reported with the use of integrase strand
transfer inhibitors (InSTI), concurrent use of tenofovir alafenamide (TAF) has been implicated …

Background We sought to identify factors associated with weight gain in randomized clinical
trials of antiretroviral therapy (ART) switch. Methods We explored the effects of demographic …