Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype …
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is caused by sarcomere gene
mutations (genotype-positive HCM) in≈ 50% of patients and occurs in the absence of …
mutations (genotype-positive HCM) in≈ 50% of patients and occurs in the absence of …
NAD+ depletion is central to placental dysfunction in an inflammatory subclass of preeclampsia
Preeclampsia (PE) is a hypertensive disorder of pregnancy and a major cause of
maternal/perinatal adverse health outcomes with no effective therapeutic strategies. Our …
maternal/perinatal adverse health outcomes with no effective therapeutic strategies. Our …
[HTML][HTML] Transcriptional Changes Associated with Amyoplasia
AE Komissarov, OE Agranovich, IA Kuchinskaia… - International Journal of …, 2024 - mdpi.com
Arthrogryposis, which represents a group of congenital disorders, includes various forms.
One such form is amyoplasia, which most commonly presents in a sporadic form in addition …
One such form is amyoplasia, which most commonly presents in a sporadic form in addition …
Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan
G Borland, SE Wilkie, J Thomson, Z Wang… - Aging …, 2024 - Wiley Online Library
The genetic pathways that modulate ageing in multicellular organisms are typically highly
conserved across wide evolutionary distances. Recently RNA polymerase III (Pol III) was …
conserved across wide evolutionary distances. Recently RNA polymerase III (Pol III) was …
NAD+ depletion and altered mitochondrial function are key to the establishment of placental dysfunction in an inflammatory-driven subclass of preeclampsia
Preeclampsia (PE) is a pregnancy associated hypertensive disease. It is one of the major
causes of pregnancy-related maternal/perinatal adverse health outcomes, with a lack of …
causes of pregnancy-related maternal/perinatal adverse health outcomes, with a lack of …
The Effects of Reduced Mrpl54 Expression on Mouse Lifespan, Metabolic Health Span, and Skeletal Muscle Aging
K Reid - 2024 - ruor.uottawa.ca
With age comes a decline in the dynamic regulation of a balanced and functional
mitochondrial proteome (proteostasis) that leads to an increase in oxidative stress and …
mitochondrial proteome (proteostasis) that leads to an increase in oxidative stress and …