Automated engineering of synthetic metabolic pathways for efficient biomanufacturing
I Otero-Muras, P Carbonell - Metabolic Engineering, 2021 - Elsevier
Metabolic engineering involves the engineering and optimization of processes from single-
cell to fermentation in order to increase production of valuable chemicals for health, food …
cell to fermentation in order to increase production of valuable chemicals for health, food …
Experimentally validated reconstruction and analysis of a genome-scale metabolic model of an anaerobic Neocallimastigomycota fungus
Anaerobic gut fungi in the phylum Neocallimastigomycota typically inhabit the digestive
tracts of large mammalian herbivores, where they play an integral role in the decomposition …
tracts of large mammalian herbivores, where they play an integral role in the decomposition …
Genome-scale metabolic models and machine learning reveal genetic determinants of antibiotic resistance in Escherichia coli and unravel the underlying metabolic …
Antimicrobial resistance (AMR) is becoming one of the largest threats to public health
worldwide, with the opportunistic pathogen Escherichia coli playing a major role in the AMR …
worldwide, with the opportunistic pathogen Escherichia coli playing a major role in the AMR …
A Multiphase Multiobjective Dynamic Genome-Scale Model Shows Different Redox Balancing among Yeast Species of the Saccharomyces Genus in Fermentation
D Henriques, R Minebois, SN Mendoza, LG Macías… - …, 2021 - Am Soc Microbiol
Yeasts constitute over 1,500 species with great potential for biotechnology. Still, the yeast
Saccharomyces cerevisiae dominates industrial applications, and many alternative …
Saccharomyces cerevisiae dominates industrial applications, and many alternative …
Reconstruction of genome-scale metabolic models of non-conventional yeasts: current state, challenges, and perspectives
ELM de Almeida, EJ Kerkhoven… - Biotechnology and …, 2024 - Springer
Non-conventional yeasts are promising cell factories to produce lipids and oleochemicals,
metabolites of industrial interest (eg., organics acids, esters, and alcohols), and enzymes …
metabolites of industrial interest (eg., organics acids, esters, and alcohols), and enzymes …
Different routes of protein folding contribute to improved protein production in Saccharomyces cerevisiae
Protein folding is often considered the flux controlling process in protein synthesis and
secretion. Here, two previously isolated Saccharomyces cerevisiae strains with increased α …
secretion. Here, two previously isolated Saccharomyces cerevisiae strains with increased α …
Panera: An innovative framework for surmounting uncertainty in microbial community modeling using pan-genera metabolic models
Utilization of 16S rRNA data in constraint-based modeling to characterize microbial
communities confronts a major hurdle of lack of species-level resolution, impeding the …
communities confronts a major hurdle of lack of species-level resolution, impeding the …
Nitrogenous compound utilization and production of volatile organic compounds among commercial wine yeasts highlight strain-specific metabolic diversity
Genetic background and environmental conditions affect the production of sensory impact
compounds by Saccharomyces cerevisiae. The relative importance of the strain-specific …
compounds by Saccharomyces cerevisiae. The relative importance of the strain-specific …
Genome-Scale Modeling Specifies the Metabolic Capabilities of Rhizophagus irregularis
P Wendering, Z Nikoloski - Msystems, 2022 - Am Soc Microbiol
Rhizophagus irregularis is one of the most extensively studied arbuscular mycorrhizal fungi
(AMF) that forms symbioses with and improves the performance of many crops. Lack of …
(AMF) that forms symbioses with and improves the performance of many crops. Lack of …
Development of a genome-scale metabolic model for the lager hybrid yeast S. pastorianus to understand the evolution of metabolic pathways in industrial settings
S Timouma, LN Balarezo-Cisneros, JM Schwartz… - Msystems, 2024 - Am Soc Microbiol
In silico tools such as genome-scale metabolic models have shown to be powerful for
metabolic engineering of microorganisms. Saccharomyces pastorianus is a complex …
metabolic engineering of microorganisms. Saccharomyces pastorianus is a complex …