Pyridines and pyrimidines are the class of heterocyclic nitrogenous compounds having
plethora of applications in anticancer drug development. These synthetic sources serve as …

Caspases, a group of protease enzymes (cysteine proteases), exist as inactive zymogens in
the cells and execute apoptosis (programmed cell death). Caspase‐3, an executioner …

Pyrazolines are five-membered heterocycles possessing two adjacent nitrogens. They have
attracted significant attention from organic and medicinal chemists due to their potent …

Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …

Pyrimidines are nitrogen-containing heterocycles known for anticancer, anti-HIV, antifungal,
and antibacterial activities. Pyrimidines, compounds bearing this heterocycle, are common …

Oxidative stress is one of the main causes of significant severe diseases. The discovery of
new potent antioxidants with high efficiency and low toxicity is a great demand in the field of …

Scaffolds hybridization is a well-known drug design strategy for antitumor agents. Herein,
series of novel indolyl-pyrimidine hybrids were synthesized and evaluated in vitro and in …

Regardless of improved biological insights and therapeutic advances, cancer is consuming
multiple lives worldwide. Cancer is a complex disease with diverse cellular, metabolic, and …

Background: The cancer is still a major cause of death worldwide. Among different targets to
design anticancer agents, caspase-3 is an important target as its cleavage and activation …

The rationale behind drug design is the strategic utilization of heterocyclic fragments with
specific physicochemical properties to form molecular targeted agents. Among the …