The maternal gut microbiome in pregnancy: implications for the developing immune system
The gut microbiome has important roles in host metabolism and immunity, and microbial
dysbiosis affects human physiology and health. Maternal immunity and microbial …
dysbiosis affects human physiology and health. Maternal immunity and microbial …
Mechanisms of fetal T cell tolerance and immune regulation
E Rackaityte, J Halkias - Frontiers in immunology, 2020 - frontiersin.org
The developing human fetus generates both tolerogenic and protective immune responses
in response to the unique requirements of gestation. Thus, a successful human pregnancy …
in response to the unique requirements of gestation. Thus, a successful human pregnancy …
[HTML][HTML] Microbial exposure during early human development primes fetal immune cells
The human fetal immune system begins to develop early during gestation; however, factors
responsible for fetal immune-priming remain elusive. We explored potential exposure to …
responsible for fetal immune-priming remain elusive. We explored potential exposure to …
Viable bacterial colonization is highly limited in the human intestine in utero
E Rackaityte, J Halkias, EM Fukui, VF Mendoza… - Nature medicine, 2020 - nature.com
Mucosal immunity develops in the human fetal intestine by 11–14 weeks of gestation, yet
whether viable microbes exist in utero and interact with the intestinal immune system is …
whether viable microbes exist in utero and interact with the intestinal immune system is …
Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis
G Sanchez Sanchez, M Papadopoulou, A Azouz… - Nature …, 2022 - nature.com
Developmental thymic waves of innate-like and adaptive-like γδ T cells have been
described, but the current understanding of γδ T cell development is mainly limited to mouse …
described, but the current understanding of γδ T cell development is mainly limited to mouse …
Understanding early-life adaptive immunity to guide interventions for pediatric health
Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …
Neonatal T cells: a reinterpretation
BD Rudd - Annual review of immunology, 2020 - annualreviews.org
Neonatal CD4+ and CD8+ T cells have historically been characterized as immature or
defective. However, recent studies prompt a reinterpretation of the functions of neonatal T …
defective. However, recent studies prompt a reinterpretation of the functions of neonatal T …
[HTML][HTML] Skin immunity: dissecting the complex biology of our body's outer barrier
C Zhang, GR Merana, T Harris-Tryon… - Mucosal …, 2022 - Elsevier
Our skin contributes critically to health via its role as a barrier tissue, carefully regulating
passage of key substrates while also providing defense against exogenous threats …
passage of key substrates while also providing defense against exogenous threats …
Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models
Accumulation of immune cells and activation of the pro-inflammatory transcription factor NF-
κB in feto-maternal uterine tissues is a key feature of preterm birth (PTB) pathophysiology …
κB in feto-maternal uterine tissues is a key feature of preterm birth (PTB) pathophysiology …
The human microbiome in the 21st century
E Rackaityte, SV Lynch - Nature communications, 2020 - nature.com
The human body supports a thriving diversity of microbes which comprise a dynamic,
ancillary, functional system that synergistically develops in lock-step with physiological …
ancillary, functional system that synergistically develops in lock-step with physiological …