Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods

M Zaiss, P Bachert - Physics in Medicine & Biology, 2013 - iopscience.iop.org
Chemical exchange saturation transfer (CEST) of metabolite protons that undergo exchange
processes with the abundant water pool enables a specific contrast for magnetic resonance …

Review and consensus recommendations on clinical APT‐weighted imaging approaches at 3T: application to brain tumors

J Zhou, M Zaiss, L Knutsson, PZ Sun… - Magnetic resonance …, 2022 - Wiley Online Library
Amide proton transfer‐weighted (APTw) MR imaging shows promise as a biomarker of brain
tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially …

Inverse Z‐spectrum analysis for spillover‐, MT‐, and T1‐corrected steady‐state pulsed CEST‐MRI – application to pH‐weighted MRI of acute stroke

M Zaiss, J Xu, S Goerke, IS Khan, RJ Singer… - NMR in …, 2014 - Wiley Online Library
Endogenous chemical exchange saturation transfer (CEST) effects are always diluted by
competing effects, such as direct water proton saturation (spillover) and semi‐solid …

Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI

A Tietze, J Blicher, IK Mikkelsen… - NMR in …, 2014 - Wiley Online Library
Chemical exchange saturation transfer (CEST)‐derived, pH‐weighted, amide proton transfer
(APT) MRI has shown promise in animal studies for the prediction of infarction risk in …

Comparing different analysis methods for quantifying the MRI amide proton transfer (APT) effect in hyperacute stroke patients

YK Tee, GWJ Harston, N Blockley, TW Okell… - NMR in …, 2014 - Wiley Online Library
Amide proton transfer (APT) imaging is a pH mapping method based on the chemical
exchange saturation transfer phenomenon that has potential for penumbra identification …

[HTML][HTML] Quantitative CEST imaging of amide proton transfer in acute ischaemic stroke

Y Msayib, GWJ Harston, YK Tee, F Sheerin… - NeuroImage: Clinical, 2019 - Elsevier
Background Amide proton transfer (APT) imaging may help identify the ischaemic penumbra
in stroke patients, the classical definition of which is a region of tissue around the ischaemic …

Quantitative Bayesian model‐based analysis of amide proton transfer MRI

MA Chappell, MJ Donahue, YK Tee… - Magnetic resonance …, 2013 - Wiley Online Library
Amide Proton Transfer (APT) reports on contrast derived from the exchange of protons
between amide groups and water. Commonly, APT contrast is quantified by asymmetry …

The Hanes‐Woolf linear QUESP method improves the measurements of fast chemical exchange rates with CEST MRI

EA Randtke, LQ Chen, LR Corrales… - Magnetic resonance in …, 2014 - Wiley Online Library
Purpose Contrast agents for chemical exchange saturation transfer MRI often require an
accurate measurement of the chemical exchange rate. Many analysis methods have been …

[HTML][HTML] Clinical translation of amide proton transfer (APT) MRI for ischemic stroke: a systematic review (2003–2020)

LS Foo, G Harston, A Mehndiratta, WS Yap… - … Imaging in Medicine …, 2021 - ncbi.nlm.nih.gov
Amide proton transfer (APT) magnetic resonance imaging (MRI) is a pH-sensitive imaging
technique that can potentially complement existing clinical imaging protocol for the …

Towards quantification of pulsed spinlock and CEST at clinical MR scanners: an analytical interleaved saturation–relaxation (ISAR) approach

V Roeloffs, C Meyer, P Bachert, M Zaiss - NMR in Biomedicine, 2015 - Wiley Online Library
Off‐resonant spinlock (SL) enables an NMR imaging technique that can detect dilute
metabolites similar to chemical exchange saturation transfer. However, in clinical MR …