The polarity of neurons, which is integral to their function, is a result of the segregated
distribution of molecules and organelles. The polarized distribution of cytoskeletal proteins …

Neurons, the basic information processing units of the nervous system, are characterized by
a complex polar morphology which is essential for their function. To attain their precise …

The amyloid β protein is deposited in the brains of patients with Alzheimer's disease but its
pathogenic role is unknown. In culture, the amyloid β protein was neurotrophic to …

We have analyzed the polarity orientation of microtubules in the axons and dendrites of
cultured rat hippocampal neurons. As previously reported of axons from other neurons …

Conflicting evidence supports a role for tau as an essential neuronal cytoskeletal protein or
as a redundant protein whose function can be fulfilled by other microtubule-associated …

A central issue in the pathogenesis of Alzheimer's disease (AD) is the relationship between
amyloid deposition and neurofibrillary tangle formation. To determine whether amyloid fibril …

Neurons form distinctive axonal and dendritic compartments that are important for directional
signaling, but the mechanisms that discriminate between axons and dendrites remain …

For nerve cells to develop their highly polarized form, appropriate structural molecules must
be targeted to either axons or dendrites. This could be achieved by the synthesis of …

In eukaryotic cells, microtubules, actin, and intermediate filaments interact to form the
cytoskeletal network involved in determination of cell architecture, intracellular transport …

In recent years, Drosophila melanogaster has emerged as a powerful model for neuronal
circuit development, pathology, and function. A major impediment to these studies has been …