RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …

The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades
of biochemistry and genetics combined with recent structural studies of the spliceosome …

The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …

Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

RNA helicases of the DEAD box family are present in all eukaryotic cells and in many
bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism …

Identifying pairwise RNA-RNA interactions is key to understanding how RNAs fold and
interact with other RNAs inside the cell. We present a high-throughput approach …

Helicases of the superfamily (SF) 1 and 2 are involved in virtually all aspects of RNA and
DNA metabolism. SF1 and SF2 helicases share a catalytic core with high structural …