Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …

Suboptimal efficacy of the current antibiotic regimens and frequent emergence of antibiotic-
resistant Mycobacterium tuberculosis (Mtb), an etiological agent of tuberculosis (TB), render …

Mycobacterium tuberculosis (Mtb) infection is difficult to treat because Mtb spends the
majority of its life cycle in a nonreplicating (NR) state. Since NR Mtb is highly tolerant to …

Marine sponges host a wide diversity of microorganisms, which have versatile modes of
carbon and energy metabolism. In this study we describe the major lithoheterotrophic and …

l-Valine, an essential amino acid, serves as a valuable compound in various industries.
However, engineering strains with both high yield and purity are yet to be delivered for …

Mycobacterium tuberculosis (Mtb) has evolved protective and detoxification mechanisms to
maintain cytoplasmic redox balance in response to exogenous oxidative stress encountered …

The approval of bedaquiline (BDQ) for the treatment of tuberculosis has generated
substantial interest in inhibiting energy metabolism as a therapeutic paradigm. However, it is …

On the basis of our previous studies of microbial L-valine production under oxygen
deprivation, we developed isobutanol-producing Corynebacterium glutamicum strains. The …

Enzymes at the phosphoenolpyruvate (PEP)–pyruvate–oxaloacetate or anaplerotic (ANA)
node control the metabolic flux to glycolysis, gluconeogenesis, and anaplerosis. Here we …

The persistence of Mycobacterium tuberculosis makes it difficult to eradicate the associated
infection from the host. The flexible nature of mycobacteria and their ability to adapt to …