Alpha‐amylase as molecular target for treatment of diabetes mellitus: A comprehensive review
The alpha (α)‐amylase is a calcium metalloenzyme that aids digestion by breaking down
polysaccharide molecules into smaller ones such as glucose and maltose. In addition, the …
polysaccharide molecules into smaller ones such as glucose and maltose. In addition, the …
Saturated five-membered thiazolidines and their derivatives: from synthesis to biological applications
In past decades, interdisciplinary research has been of great interest for scholars.
Thiazolidine motifs behave as a bridge between organic synthesis and medicinal chemistry …
Thiazolidine motifs behave as a bridge between organic synthesis and medicinal chemistry …
In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities …
AS Hassan, NM Morsy… - Drug Development …, 2023 - Wiley Online Library
The strategy of utilizing nitrogen compounds in various biological applications has recently
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
[HTML][HTML] Exploration of Cannabis constituents as potential candidates against diabetes mellitus disease using molecular docking, dynamics simulations and ADMET …
Diabetes Mellitus is one of the deadliest diseases in the world, while the current medications
against this disease like acarbose represent many side effects such as diarrhea and …
against this disease like acarbose represent many side effects such as diarrhea and …
Discovery of novel coumarin derivatives as potential dual inhibitors against α-glucosidase and α-amylase for the management of post-prandial hyperglycemia via …
Coumarin derivatives are proven for their therapeutic uses in several human diseases and
disorders such as inflammation, neurodegenerative disorders, cancer, fertility, and microbial …
disorders such as inflammation, neurodegenerative disorders, cancer, fertility, and microbial …
In vitro and in silico studies of fluorinated 2, 3‐disubstituted thiazolidinone‐pyrazoles as potential α‐amylase inhibitors and antioxidant agents
As part of our effort to identify potent α‐amylase inhibitors, in the present study, a novel
series of fluorinated thiazolidinone‐pyrazole hybrid molecules were prepared by the …
series of fluorinated thiazolidinone‐pyrazole hybrid molecules were prepared by the …
Chemical Composition, Antibacterial, Antifungal and Antidiabetic Activities of Ethanolic Extracts of Opuntia dillenii Fruits Collected from Morocco
ELH Loukili, B Bouchal, M Bouhrim… - Journal of Food …, 2022 - Wiley Online Library
Opuntia dillenii (Ker Gawl.) Haw. belongs to the Cactaceae family and is native to the arid
and semi‐arid regions of Mexico and the southern United States. O. dillenii are now used as …
and semi‐arid regions of Mexico and the southern United States. O. dillenii are now used as …
An insight of alpha-amylase inhibitors as a valuable tool in the management of type 2 diabetes mellitus
R Bashary, M Vyas, SK Nayak, A Suttee… - Current diabetes …, 2020 - ingentaconnect.com
Background: Among the millions of people around the world, the most prevalent metabolic
disorder is diabetes mellitus. Due to the drawbacks which are associated with commercially …
disorder is diabetes mellitus. Due to the drawbacks which are associated with commercially …
Exploring biological efficacy of novel benzothiazole linked 2, 5-disubstituted-1, 3, 4-oxadiazole hybrids as efficient α-amylase inhibitors: Synthesis, characterization …
In an effort to explore a class of novel antidiabetic agents, we have made an effort to
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
Synthesis, characterization, α-glucosidase inhibition and molecular modeling studies of some pyrazoline-1H-1, 2, 3-triazole hybrids
A series of molecular hybrids based on pyrazoline and 1, 2, 3-triazole pharmacophores
were designed and synthesized as antidiabetic agents. The structures of all the derivatives …
were designed and synthesized as antidiabetic agents. The structures of all the derivatives …