Eukaryotic chromatin is kept flexible and dynamic to respond to environmental, metabolic,
and developmental cues through the action of a family of so-called “nucleosome …

Chromatin dynamics play an essential role in regulating the accessibility of genomic DNA for
a variety of nuclear processes, including gene transcription and DNA repair. The …

Set2-mediated methylation of histone H3 Lys36 (H3K36) is a mark associated with the
coding sequences of actively transcribed genes, but it has a negative role during …

Covalent modifications of histone proteins play key roles in transcription, DNA repair,
recombination, and other such processes. Over a hundred histone modifications have been …

Deletion of the gene encoding the chromatin remodeler CHD1 is among the most common
alterations in prostate cancer (PCa); however, the tumor-suppressive functions of CHD1 and …

Chromatin remodelers use the energy of ATP hydrolysis to reposition or evict nucleosomes
or to replace canonical histones with histone variants. By regulating nucleosome dynamics …

It is well established that ATP-dependent chromatin remodelers modulate DNA access of
transcription factors and RNA polymerases by" opening" or" closing" chromatin structure …

Regulation of chromatin structure is critical for brain development and function. However, the
involvement of chromatin dynamics in neurodegeneration is less well understood. Here we …

The ATP‐dependent chromatin‐remodelling enzyme Chd1 is a 168‐kDa protein consisting
of a double chromodomain, Snf2‐related ATPase domain, and a C‐terminal DNA‐binding …

The chromodomain motif is found among certain chromosomal proteins of all eukaryotes.
The chromodomain fold–three beta strands packed against a C-terminal alpha helix …