For the past century, experimental data obtained from animal studies have been required by
reviewers of scientific articles and grant applications to validate the physiological relevance …

Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in
vitro cell culture that has a promising future in the healthcare industry. The numerous …

Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …

Organs-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced
in vitro tools able to replicate essential functions of human organs. Owing to their …

Organ-on-a-chip (OOC) is a very ambitious emerging technology with a high potential to
revolutionize many medical and industrial sectors, particularly in preclinical-to-clinical …

Background & Aims Drug-induced liver injury (DILI), both intrinsic and idiosyncratic, causes
frequent morbidity, mortality, clinical trial failures and post-approval withdrawal. This …

Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …

Bone diseases, such as osteoporosis and bone defects, often lead to structural and
functional deformities of the patient's body. Understanding the complicated pathophysiology …

Human Microphysiological Systems (hMPS), otherwise known as organ-and tissue-on-a-
chip models, are an emerging technology with the potential to replace in vivo animal studies …

With the increasing importance of preclinical evaluation of newly developed drugs or
treatments, in vitro organ or disease models are necessary. Although various organ-specific …