TMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium‐
activated chloride channels, with ten transmembrane segments. Recently, atomic structures …

Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment
of neuropathic pain. The analgesia lasts for several months after a single treatment …

Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride
channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth …

The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction
due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis …

Abstract Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca 2+ activated Cl–
channels (CaCCs) that are critical for physiological functions, such as epithelial secretion …

In contrast to pain processing neurons in the spinal cord, where the importance of chloride
conductances is already well established, chloride homeostasis in primary afferent neurons …

Abstract The TMEM16A-mediated Ca 2+-activated Cl− current drives several important
physiological functions. Membrane lipids regulate ion channels and transporters but their …

Abstract Background Transmembrane protein 16A (TMEM16A) Ca 2+-activated Cl−
channels have diverse physiological functions, such as epithelial secretion of Cl− and fluid …

Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely
on calcium activation to perform their functions. In 2008, TMEM16A (also known as …

Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin
family of calcium-activated chloride channels with diverse cellular functions. ANO1 controls …