The effects of chronic stress on the human brain: From neurotoxicity, to vulnerability, to opportunity
For the last five decades, science has managed to delineate the mechanisms by which
stress hormones can impact on the human brain. Receptors for glucocorticoids are found in …
stress hormones can impact on the human brain. Receptors for glucocorticoids are found in …
[HTML][HTML] Neurobiology and consequences of social isolation stress in animal model—A comprehensive review
The brain is a vital organ, susceptible to alterations under genetic influences and
environmental experiences. Social isolation (SI) acts as a stressor which results in …
environmental experiences. Social isolation (SI) acts as a stressor which results in …
Cortisol and major depressive disorder—translating findings from humans to animal models and back
Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
[HTML][HTML] The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer's disease
Alzheimer's Disease (AD) is the leading cause of dementia, observed at a higher incidence
in women compared with men. Treatments aimed at improving pathology in AD remain …
in women compared with men. Treatments aimed at improving pathology in AD remain …
Acute and long-term effects of adolescence stress exposure on rodent adult hippocampal neurogenesis, cognition, and behaviour
A Borsini, J Giacobbe, G Mandal, M Boldrini - Molecular Psychiatry, 2023 - nature.com
Adolescence represents a critical period for brain and behavioural health and characterised
by the onset of mood, psychotic and anxiety disorders. In rodents, neurogenesis is very …
by the onset of mood, psychotic and anxiety disorders. In rodents, neurogenesis is very …
The role of HPA axis and allopregnanolone on the neurobiology of major depressive disorders and PTSD
Under stressful conditions, the hypothalamic-pituitary-adrenal (HPA) axis acts to promote
transitory physiological adaptations that are often resolved after the stressful stimulus is no …
transitory physiological adaptations that are often resolved after the stressful stimulus is no …
A comprehensive approach to modeling maternal immune activation in rodents
MC Bucknor, A Gururajan, RC Dale… - Frontiers in …, 2022 - frontiersin.org
Prenatal brain development is a highly orchestrated process, making it a very vulnerable
window to perturbations. Maternal stress and subsequent inflammation during pregnancy …
window to perturbations. Maternal stress and subsequent inflammation during pregnancy …
Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice
Chronic psychological stress is one of the most important triggers and environmental risk
factors for neuropsychiatric disorders. Chronic stress can influence all organs via the …
factors for neuropsychiatric disorders. Chronic stress can influence all organs via the …
Hippocampal BDNF in physiological conditions and social isolation
Exposure of an organism to chronic psychosocial stress may affect brain-derived
neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric …
neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric …
The evidence for altered BDNF expression in the brain of rats reared or housed in social isolation: a systematic review
J Murínová, N Hlaváčová, M Chmelová… - Frontiers in behavioral …, 2017 - frontiersin.org
There is evidence that development and maintenance of neural connections are disrupted in
major mental disorders, which indicates that neurotrophic factors could play a critical role in …
major mental disorders, which indicates that neurotrophic factors could play a critical role in …