Liposomes and extracellular vesicles as drug delivery systems: A comparison of composition, pharmacokinetics, and functionalization

L van der Koog, TB Gandek… - Advanced healthcare …, 2022 - Wiley Online Library
Over the past decades, lipid‐based nanoparticle drug delivery systems (DDS) have caught
the attention of researchers worldwide, encouraging the field to rapidly develop improved …

How liposomes pave the way for ocular drug delivery after topical administration

N Tasharrofi, M Nourozi, A Marzban - Journal of Drug Delivery Science and …, 2022 - Elsevier
The eye is one of the most specialized organs in the body; one of its flawless functions is
vigorously controlling the foreign materials' entrance to the eye. On the other hand, this …

Physicochemical characterization of liposomes that mimic the lipid composition of exosomes for effective intracellular trafficking

K Sakai-Kato, K Yoshida, Y Takechi-Haraya, K Izutsu - Langmuir, 2020 - ACS Publications
Exosomes mediate communication between cells in the body by the incorporation and
transfer of biological materials. To design an artificial liposome, which would mimic the lipid …

[HTML][HTML] Atomic force microscopy measurements of anionic liposomes reveal the effect of liposomal rigidity on antigen-specific regulatory T cell responses

N Benne, RJT Leboux, M Glandrup, J van Duijn… - Journal of Controlled …, 2020 - Elsevier
Regulatory T cells (Tregs) are vital for maintaining a balanced immune response and their
dysfunction is often associated with auto-immune disorders. We have previously shown that …

Lipid composition is critical for accurate membrane permeability prediction of cyclic peptides by molecular dynamics simulations

M Sugita, T Fujie, K Yanagisawa, M Ohue… - Journal of Chemical …, 2022 - ACS Publications
Cyclic peptides have attracted attention as a promising pharmaceutical modality due to their
potential to selectively inhibit previously undruggable targets, such as intracellular protein …

Exploring the influence of inhaled liposome membrane fluidity on its interaction with pulmonary physiological barriers

J Zhao, J Su, L Qin, X Zhang, S Mao - Biomaterials Science, 2020 - pubs.rsc.org
Liposomes are promising vectors for pulmonary drug delivery, and have been used in
marketed inhalation products. Membrane fluidity is an important property of liposomes …

[HTML][HTML] Active probing of the mechanical properties of biological and synthetic vesicles

MC Piontek, RB Lira, WH Roos - Biochimica et Biophysica Acta (BBA) …, 2021 - Elsevier
Background The interest in mechanics of synthetic and biological vesicles has been
continuously growing during the last decades. Liposomes serve as model systems for …

Control of liposomal penetration into three-dimensional multicellular tumor spheroids by modulating liposomal membrane rigidity

Y Takechi-Haraya, Y Goda… - Molecular …, 2017 - ACS Publications
Effective penetration of drug-carrying nanoparticles into solid tumors is a major challenge in
cancer therapy. Exploration of the physicochemical properties of nanoparticles that affect …

Atomic force microscopy study on the stiffness of nanosized liposomes containing charged lipids

Y Takechi-Haraya, Y Goda, K Sakai-Kato - Langmuir, 2018 - ACS Publications
It has recently been recognized that the mechanical properties of lipid nanoparticles play an
important role during in vitro and in vivo behaviors such as cellular uptake, blood circulation …

Characterization of liposomal carriers for the trans-scleral transport of Ranibizumab

RR Joseph, DWN Tan, MRM Ramon, JV Natarajan… - Scientific reports, 2017 - nature.com
Age-related macular degeneration (AMD) is a leading cause of blindness in the modern
world. The standard treatment regimen for neovascular AMD is the monthly/bimonthly …