Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …

It is now clearly established that complex interactions between genes and environment are
involved in multiple aspects of neuropsychiatric disorders, from determining an individual's …

The maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the
protracted timing of human brain development, extending over months to years for reaching …

Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

Alternative splicing of pre-mRNA increases genetic diversity, and recent studies estimate
that most human multiexon genes are alternatively spliced. If this process is not highly …

Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an
epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely …

Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with
impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other …

Microexons represent the most highly conserved class of alternative splicing, yet their
functions are poorly understood. Here, we focus on closely related neuronal microexons …

Stress during sensitive developmental periods can adversely affect physical and
psychological development and contribute to later-life mental disorders. In particular …

The maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the
protracted timing of human brain development, extending over months and years to reach …