Gut bacteria influence brain functions and metabolism. We investigated whether this
influence can be mediated by direct sensing of bacterial cell wall components by brain …

Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …

Sphingolipids are essential components of eukaryotic cells. In this review, we want to
exemplarily illustrate what is known about the interactions of sphingolipids with various …

Abstract The PI3K/AKT pathway plays an essential role in tumour development. NOD-like
receptors (NLRs) regulate innate immunity and are implicated in cancer, but whether they …

Background Receptor-interacting protein kinase 2 (RIPK2) is a serine/threonine kinase
whose activity propagates inflammatory signaling through its association with pattern …

As an intracellular pattern recognition receptor (PPR), the nucleotide-binding
oligomerization domain-containing protein 2 (NOD2) triggers a cascade of immune …

Immune cells must be able to adjust their metabolic programs to effectively carry out their
effector functions. Here, we show that the endoplasmic reticulum (ER) stress sensor Inositol …

Asthma is an extremely prevalent chronic inflammatory disease of the airway where innate
and adaptive immune systems participate collectively with epithelial and other structural …

The innate immune system provides an adequate response to stress factors and pathogens
through pattern recognition receptors (PRRs), located on the surface of cell membranes and …

Background & Aims Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) is a
central player in triggering necroptotic cell death. However, whether macrophage RIPK3 …