Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the
most important functions of these metabolically active cells is mineralized matrix production …

Abstract Purpose of Review The periosteum, the outer layer of bone, is a major source of
skeletal stem/progenitor cells (SSPCs) for bone repair. Here, we discuss recent findings on …

A fundamental question in bone biology concerns the contributions of skeletal
stem/progenitor cells (SSCs) in the bone marrow versus the periosteum to bone repair. We …

Vertebral bone is subject to a distinct set of disease processes from long bones, including a
much higher rate of solid tumour metastases,,–. The basis for this distinct biology of vertebral …

Objectives Synovium is acutely affected following joint trauma and contributes to post-
traumatic osteoarthritis (PTOA) progression. Little is known about discrete cell types and …

The ontogeny and fate of stem cells have been extensively investigated by lineage-tracing
approaches. At distinct anatomical sites, bone tissue harbors multiple types of skeletal stem …

A distinct population of skeletal stem/progenitor cells (SSPCs) has been identified that is
indispensable for the maintenance and remodeling of the adult skeleton. However, the cell …

Self-renewal and differentiation of skeletal stem and progenitor cells (SSPCs) are tightly
regulated processes, with SSPC dysregulation leading to progressive bone disease. While …

We have previously reported that the cortical bone thinning seen in mice lacking the Wnt
signaling antagonist Sfrp4 is due in part to impaired periosteal apposition. The periosteum …

The tissue-resident skeletal stem cells (SSCs), which are self-renewal and multipotent,
continuously provide cells (including chondrocytes, bone cells, marrow adipocytes, and …