Investigation of the marine sponge Agelas dispar MeOH fractions using feature-based
molecular networking, dereplication, and isolation led to the discovery of new bromopyrrole …

Covering period: up to 2019 Water-soluble natural products constitute a relevant group of
secondary metabolites notably known for presenting potent biological activities. Examples …

Covering: 2017–2019 Guanidine natural products isolated from microorganisms, marine
invertebrates and terrestrial plants, amphibians and spiders, represented by non-ribosomal …

The marine polyclad flatworm Planocera multitentaculata is known to possess high levels of
tetrodotoxin (TTX), but the presence of TTX analogues in the species has been unexplored …

The biosynthesis of tetrodotoxin (TTX, 1), a potent neurotoxin widely distributed in marine
and terrestrial metazoans, remains unresolved. A significant issue has been identifying …

Throughout history, humans have encountered natural toxic chemicals from the ocean
environment, often through contaminated seafood. Although marine toxins can be harmful to …

Paralytic shellfish toxins (PSTs) are the major neurotoxic contaminants of edible bivalves in
Japan. Tetrodotoxin (TTX) was recently detected in bivalve shellfish around the world …

A total synthesis of tetrodotoxin was accomplished. A Diels–Alder reaction between a known
enone and a siloxy diene gave a tricyclic product, the steric bias of which was used to …

Tetrodotoxin (TTX), known as pufferfish toxin, is a potent neurotoxin blocking sodium
channels in muscle and nerve tissues. TTX has been detected in various taxa other than …

Tetrodotoxin (TTX), one of the most potent naturally occurring neurotoxins, has been
detected in both marine and terrestrial organisms. The marine polyclad flatworm Planocera …